I've just spent the whole night setting up blog comments. PyBlosxom doesn't make it painless, sadly, more like the opposite. First: don't be scared by the list of comment-related plugins on the PyBlosxom site. There's only one important plugin: comments. All others depend on it and enhance its functionality. The last three or four times I was about to add comments to my blog I got scared at step one: evaluate the available plugins.